Ghulam Murtaza

I am a postdoctoral researcher in the Department of Genome Sciences at the University of Washington, working with Prof. William Stafford Noble. During my postdoc, I am developing methods to study the role of 3D genome organization in gene regulation. I am building foundation model for Hi-C data that is robust to many sources of missingness. I am using this new foundation model to study the rules that govern gene regulation at both bulk and single-cell resolution.

My earlier work developed graph-based deep-learning methods for the 3D genome. I created GrapHiC, which imputes missing Hi-C reads by integrating epigenomic signals into a graph representation, and scGrapHiC, which recovers cell-type-specific pseudobulk single-cell Hi-C (scHi-C) contact matrices from a bulk Hi-C measurement and widely available single-cell gene expression.

I completed my Ph.D. in Computer Science at Brown University with Dr. Ritambhara Singh, where my dissertation connected sequential and structural genomics through graph-based representations. Earlier, I earned my B.S. in Computer Science from the Lahore University of Management Sciences.